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Modulación del Inflamasoma por Leishmania
Resumen
Las células presentadoras de antígeno, como los macrófagos y las células dendríticas, desencadenan vías de señalización que generan diversas moléculas efectoras importantes para la regulación de la respuesta inmune. En la leishmaniasis, el parásito Leishmania interrumpe diversas vías de señalización para manipular la respuesta inmune del hospedero con la finalidad de evitar ser eliminado y poder establecer una infección. Se ha descrito en muchos reportes que diferentes especies de Leishmania regulan dichas vías de señalización de manera diferencial. Por lo tanto, el objetivo del presente trabajo era hacer una revisión bibliográfica descriptiva para analizar cómo diferentes especies de Leishmania modulan la señalización del hospedero mamífero por la vía canónica y no canónica de la activación del inflamasoma. También se examina tanto el papel de la IL-1β y los polimorfismos del gen de IL-1β en la leishmaniasis como la manera en que algunos fármacos antileishmanicidas modulan el inflamasoma. Las bases de datos que se utilizaron para buscar artículos relevantes fueron Pubmed, Science Direct, y Clinical Key.
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