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Human papillomavirus 13 L1 gene polimorphism: first report.
Resumen
Abstract
Introduction. Human papillomavirus 13 (HPV-13) belonging to Alphapapillomavirus-10 species, is an oral mucosotropic virus phylogenetically related to others human papillomavirus (6, 11, 44, 55 and 74). It causes Multifocal Epithelial Hyperplasia, an uncommon benign oral disease reported mainly amongst ethnic groups from America.
Objective. To describe the genetic variability of the HPV-13 L1 gene.
Material and Methods. A retrospective study including 50 oral samples from patients with Multifocal Epithelial Hyperplasia, and 25 samples from asymptomatic carriers of HPV-13, all subjects living in Mayan area of Mexico. A fragment 240 bp corresponding to the HPV 13L1 gene, which encodes the major capsid protein was amplified, sequenced, and compared with the only two reference sequence of HPV-13 available. A phylogenetic tree was constructed using PAUP* software.
Results. Eight single nucleotide polymorphisms were identified including three synonymous polymorphism and five non-synonymous. According to the phylogenetic tree, the variants were grouped in two branches.
Conclusion: This is the first study of the genetic variability of HPV-13. A dominant polymorphism shared by patients and asymptomatic carriers was identified.
Referencias
- de Villiers EM, Fauquet C, Broker TR, Bernard HU, zur Hausen H. Classification of papillomaviruses. Virology. 2004 Jun; 20;324(1):17-7. doi: 10.1016/j.virol.2004.03.033.
- Bernard HU, Burk RD, Chen Z, van Doorslaer K, zur Hausen H, de Villiers EM. Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology. 2010 May; 401(1):70-79. doi: 10.1016/j.virol.2010.02.002.
- Pfister H, Hettich I, Runne U, Gissmann L, Chilf GN. Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions. J. Virol. 1983 Aug;
(2): 363-6. doi:10.1128/JVI.47.2.363-366.
- Van Ranst M, Fuse A, Fiten P, Beuken E, Pfister H, Burk RD, Opdenakker G. Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1: comparison of the genome organizations. Virology. 1992 Oct;190(2):587-96. doi: 10.1016/0042-6822(92)90896-w.
- Santos PP, Vasconcelos MG, Pereira KMA, de Souza LB, de A. Freitas R, de L.L. Costa A, et al. Hiperplasia epitelial focal (doença de Heck) em descendente de indios brasileiros: relato de caso. J. Bras. Patol. e Med. Lab. 2007 Dec; 43 (6): 431–4. available: https://www.scielo.br/j/jbpml/a/Xg7FFxxkhr9wkd8xHrnN9hN/
- Cuberos V, Perez J, Lopez CJ, Castro F, Gonzalez LV, Correa LA, et al. Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: A case-control study. J. Clin. Virol. 2066 Sep;37(1):21-6. doi: 10.1016/j.jcv.2006.04.003.
- Roman CB, Sedano HO. Multifocal papilloma virus epithelial hiperplasia. Oral Surg Oral Med Oral Pathol 1994 Jun;77(6):631-5. doi: 10.1016/0030-4220(94)90325-5.
- Lopez-Villanueva ME, Conde-Ferráez L, Ayora-Talavera G, Cerón-Espinosa JD, González-Losa MR. Human papillomavirus 13 in a Mexican Mayan community with multifocal epithelial hyperplasia: Could saliva be involved in household transmission?
Eur. J. Dermatology. 2011 May-Jun;21(3):396-400. doi: 10.1684/ejd.2011.1347.
- González-Losa M del R, Suarez-Allén RE, Canul-Canche J, Conde-Ferráez L, Eljure Lopez N. Multifocal epithelial hyperplasia in a community in the Mayan area of Mexico. Int. J. Dermato. 2011 March; 50 (3) : 304–309. doi: 10.1111/j.1365 4632.2010.04718.x.
- Zavala-García A, Briceño-Mena R, Romero-Beltran L, Kelly GA, Cerón-Espinosa JD, González-Losa MR. Epithelial Focal Hyplerplasia Prevalence in an endemic population. Molecular association of hpv 13 to asymptomatic patients and comparison between three elementary school of different income levels. J Immuno Biol 2017, 2:4 doi:10.4172/2476-1966.1000133
- Ozden B, Gunduz K, Gunhan O, Ozden FO. A Case Report of Focal Epithelial Hyperplasia (Heck’s disease) with PCR Detection of Human Papillomavirus. J Maxillofac Oral Surg. 2011 Dec;10(4):357-60. doi: 10.1007/s12663-011-0184-2.
- Ledesma-Montes C, Garcés-Ortíz M, Edmundo B. Multifocal Epithelial Hyperplasia. An Unusual Lesion. Case Report. Webmed Cent. Pathol. 2012 Feb; 3 (2):1
https://www.researchgate.net/publication/272564352_
- Sarabadani J, Heydari S, Mashreghi A, Poornazari N. A Case Report of Multifocal Epithelial Hyperplasia (Heck’s Disease) Treated with CO 2 Laser. J Dent Mater Tech. 2017 June; 6(3): 138–41. doi:10.22038/JDMT.2017.8992
- King AJ, Sonsma JA, Vriend HJ, van der Sande MAB, Feltkamp MC, Boot HJ, et al Genetic Diversity in the Major Capsid L1 Protein of HPV-16 and HPV-18 in the Netherlands. PLoS One . 2016 Apr 12;11(4):e0152782. doi: 10.1371/journal.pone.0152782
- Fang L, Lin X, Yang Y, Song Z, Ding X, Tan L, Gao P. Genetic variability, phylogeny and functional implication of the long control region in human papillomavirus ype 16, 18 and 58 in Chengdu, China. Virol J . 2020 Jul 16;17(1):106.
doi: 10.1186/s12985-020-01349-3.
- Williamson A-L, Dennis SJ. The use of the polymerase chain reaction for the detection of human papillomavirus type 13. J Virol Methods. 1991 Jan;31(1):57-65. doi: 10.1016/0166-0934(91)90144-o.
- Kearse M, Moir R, Wilson A, Stones-Havas S, Cheung M, Sturrock S, et al. Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data. Bioinformatics . 2012 Jun ;28(12):1647-9.
doi: 10.1093/bioinformatics/bts199.
- Yang J, Zhang Y. I-TASSER server: New development for protein structure and function predictions. Nucleic Acids Research. 2015 Jul; 43(W1):W174-81. doi:org/10.1093/nar/gkv342
- Zhang C, Freddolino PL, Zhang Y. COFACTOR: Improved protein function prediction by combining structure, sequence and protein-protein interaction information. Nucleic Acids Res . 2017 Jul 3;45(W1):W291-W299. doi:10.1093/nar/gkx366.
- Faus H & Dillner J. Mutations in human papillomavirus type 16 L1 hypervariable surface exposed loops affect L2 binding and DNA encapsidation. J Gen Virol . 2013 Aug;94(8):1841-1849. doi: 10.1099/vir.0.054205-0.
- Olcese VA, Chen Y, Schlegel R, Yuan H. Characterization of HPV16 L1 loop domains in the formation of a type-specific, conformational epitope. BMC Microbiol . 2004 Jul 19; 4:29. doi: 10.1186/1471-2180-4-29.
- Calleja-Macias IE, Villa LL, Prado JC, Allan B, Williamson A, Collins RJ. et al. Worldwide genomic diversity of the high-risk human papillomavirus types 31, 35, 52, and 58, four close relatives of human papillomavirus type 16. J Virol . 2005 Nov;79(21):13630-40. doi: 10.1128/JVI.79.21.13630-13640.2005.
- Liu JH, Lu ZT, Wang GL, Zhou WQ, Liu C, Yang LX. Variations of human papillomavirus type 58 E6, E7, L1 genes and long control region in strains from women with cervical lesions in Liaoning province, China. Infect Genet Evol . 2012 Oct;12(7):1466-72. doi: 10.1016/j.meegid.2012.05.004.
- Chen Z, Schiffman M, Herrero R, DeSalle R, Anastos K, Segondy M, et al. Evolution and taxonomic classification of human papillomavirus 16 (HPV16)-related variant genomes: HPV31, HPV33, HPV35, HPV52, HPV58 and HPV67. PLoS One . 2011;6(5):e20183. doi: 10.1371/journal.pone.0020183
- Yamada T, Manos MM, Peto J, Greer CE, Munoz NN, Bosch FX et al. Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective. J Virol. 1997 Mar;71(3):2463-72. doi: 10.1128/JVI.71.3.2463-2472.1997.
- Xi LF, Koutsky LA, Hildesheim A, Galloway DA, Wheeler CM, Winer RL. Risk for High-Grade Cervical Intraepithelial Neoplasia Associated with Variants of Human Papillomavirus Types 16 and 18. Cancer Epidemiol Biomarkers Prev . 2007 Jan;16(1):4-10. doi: 10.1158/1055-9965.EPI-06-0670.
- Pande S, Jain N, Prusty BK, Bhambhani S, Gupta S, Sharma R, et al. Human papillomavirus type 16 variant analysis of E6, E7, and L1 genes and long control region in biopsy samples from cervical cancer patients in North India. J Clin Microbiol.
Mar;46(3):1060-6. doi: 10.1128/JCM.02202-07.
- Sun ZR, Ren G, Cui X, Zhou WQ, Liu C, Ruan Q. Genetic diversity of HPV-16 E6, E7, and L1 genes in women with cervical lesions in Liaoning Province, China. Int J Gynecol Cancer. 2011 Apr;21(3):551-8. doi: 10.1097/IGC.0b013e3182112023.
- Harari A, Chen Z, Burk RD. Human Papillomavirus Genomics: Past, Present and Future. In: Hum. Papillomavirus Bench to Bedside. Germany: Karger;2012. P. 1–18.
- Villiers E-M de. Cross-roads in the classification of papillomaviruses. Virology . 2013 Oct;445(1-2):2-10. doi: 10.1016/j.virol.2013.04.023
- Bishop B, Dasgupta J, Klein M, Garcea RL, Christensen ND, Zhao R, Chen XS. Crystal structures of four types of human papillomavirus L1 capsid proteins: Understanding
the specificity of neutralizing monoclonal antibodies. J Biol Chem . 2007 Oct 26;282(43):31803-11. doi: 10.1074/jbc.M706380200.
- Xia L, Xian Y, Wang D, Chen Y, Huang X, Bi X, et al. A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially
overlapping with that of H16.V5. Sci Rep . 2016 Jan 11;6:19042. doi: 10.1038/srep19042.
- Culp TD, Spatz CM, Reed CA, Christensen ND. Binding and neutralization efficiencies of monoclonal antibodies, Fab fragments, and scFv specific for L1 epitopes on the capsid of infectious HPV particles. Virology. 2007 May 10;361(2):435-46.
doi: 10.1016/j.virol.2006.12.002.
- Thönes N, Herreiner A, Schädlich L, Piuko K, Muller M. A Direct Comparison of Human Papillomavirus Type 16 L1 Particles Reveals a Lower Immunogenicity of Capsomeres than Viruslike Particles with Respect to the Induced Antibody Response. J Virol. 2008 Jun;82(11):5472-85. doi: 10.1128/JVI.02482-07.
-El-Aliani A, El-Alaoui MA, Chaoui I, Ennaji MM, Attaleb M, El-Mzibri M. Naturally occurring capsid protein variants L1 of human papillomavirus genotype 16 in Morocco. Bioinformation 2017 Aug 31;13(8):241-248. doi: 10.6026/97320630013241
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