DOI: https://doi.org/10.32776/revbiomed.v28i2.560

piRNAs, un nuevo campo de biomarcadores en cáncer

Joaquín Pérez-Alvarado, José Miguel Moreno-Ortiz

Resumen

Los piRNA son secuencias de 24 a 32 nucleótidos asociados a proteínas piwi de la familia argonauta, la cual posee propiedad endonucleasa. Son sintetizados a partir de regiones intergénicas repetitivas y su principal función es el silenciamiento de transposones, sin embargo, se ha encontrado que su descontrol esta asociado con el desarrollo de diversos tipos de cancer. Varios piRNAs han sido propuestos como biomarcadores del desarrollo tumoral, sin embargo no en todos los tipos de cancer han sido estudiados, investigaciones recientes muestran que cancer de mama y cancer gástrico son lo que encabezan la lista con un mayor número de publicaciones. Por lo que el presente trabajo se centra en conocer los piRNAs de mayor relevancia en tipos específicos de cáncer, con la finalidad de que se promueva su análisis en aquellos cánceres poco estudiados o que predominan epidemiológicamente en ciertas poblaciones.

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DOI: https://doi.org/10.32776/revbiomed.v28i2.560

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