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Adenovirus Humano Tipo 36 (Ad36) se relaciona con un mejor perfil lipídico en niños Mexicanos pero no con obesidad
Resumen
Introducción. La obesidad y su comorbilidad son de las principales causas de muerte en México, es una enfermedad multifactorial, en la que se ha visto además la participación de un agente infeccioso. Ad36 se ha asociado con obesidad, pero paradójicamente también con niveles más bajos de glucosa, colesterol y triglicéridos, sin embargo, existe controversia en diferentes poblaciones. Objetivo. Evaluar la asociación de anticuerpos antiAd36 con variables antropométricas y bioquímicas. Material y métodos. Estudio transversal en 299 niños mexicanos mestizos en edad escolar (6 a 12 años). Se obtuvieron mediciones antropométricas de altura, peso corporal, circunferencia de la cintura, grosor del pliegue cutáneo del tríceps, se calculó índice de masa corporal (IMC) y relación cintura/ altura. Las variables bioquímicas incluyeron niveles séricos de glucosa, triglicéridos, colesterol total, lipoproteínas de alta densidad y lipoproteínas de baja densidad. Se utilizó un ensayo inmunoabsorbente ligado a enzimas (ELISA) para determinar los anticuerpos contra Ad36 en las muestras de suero. Resultados. Los anticuerpos anti-Ad36 se asociaron con niveles más bajos de colesterol sérico total (β = -0.133, p = 0.021) y LDL (β = -0.166, p = 0.004), y con niveles más altos de HDL (β = 0.120, p = 0.037), pero no con obesidad. Conclusión. En resumen, la exposición previa a Ad36 se asoció con un mejor perfil lipídico en niños mexicanos, independientemente de la obesidad
Background. Obesity and its comorbidities are one of the main causes of death in Mexico; it is a multifactorial disease, in which the participation of an infectious agent has been evaluated. Ad36 is associated with obesity, but paradoxically also with lower levels of glucose, cholesterol and triglycerides; however, there is controversy in different populations. Objective. To evaluate the association of antibodies against Ad36 with anthropometric and biochemical variables. Material and Methods. Cross-sectional study in 299 Mexican-mestizo children of elementary schools (6-12 years old). Anthropometric measurements of height, body weight, waist circumference, thickness of the triceps skin fold were obtained; body mass index (BMI) and waist / height ratio were calculated. Biochemical variables included serum glucose, triglycerides, total cholesterol, high-density lipoproteins, and low-density lipoproteins. An enzyme-linked immunosorbent assay (ELISA) was used to determine antibodies against Ad36 in serum samples. Results. Anti-Ad36 antibodies were associated with lower levels of total serum cholesterol (β = -0.133, p = 0.021) and LDL (β = -0.166, p = 0.004), and with higher levels of HDL (β = 0.120, p = 0.037), but not with obesity. Conclusion. Previous exposure to Ad36 was associated with a better lipid profile in Mexican children, regardless of obesity
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