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Aplicaciones clínicas de miR-21: Revisión de la literatura
Resumen
hsa-micro RNA-21 (miR-21) es uno de los micro RNAs más estudiados debido al gran número de procesos en los que está involucrado y células en donde se expresa. Aunque la mayor parte de la investigación se ha dirigido a su papel en el cáncer, se ha encontrado que es un elemento regulador relevante en procesos fisiológicos y patológicos de virtualmente todos los sistemas. Esta revisión descriptiva resume la investigación más reciente realizada respecto a sus funciones biológicas y las potenciales aplicaciones clínicas como biomarcador y blanco terapéutico. Se realizó una búsqueda de “hsa-miR-21” en la base de datos de Pubmed y se seleccionaron los 50 artículos originales más recientes, con no más de cinco que se enfocaran en un solo sistema o área de especialidad. Esta revisión proporciona una visión general de las formas en que esta molécula influye la salud y los beneficios que su investigación podría proporcionar en el futuro para la supervivencia y calidad de vida de una variedad de pacientes.
Palabras Clave: miR-21, aplicaciones clínicas, biomedicina.
Referencias
REFERENCIAS
Wang S, Wan X, Ruan Q. The MicroRNA-21 in Autoimmune Diseases. Int J Mol Sci. 2016 Jun 3;17(6):864. doi: 10.3390/ijms17060864. PMID: 27271606; PMCID: PMC4926398.
Saliminejad K, Khorram Khorshid HR, Soleymani Fard S, Ghaffari SH. An overview of microRNAs: Biology, functions, therapeutics, and analysis methods. J Cell Physiol. 2019 May;234(5):5451-5465. doi: 10.1002/jcp.27486. Epub 2018 Nov 23. PMID: 30471116.
Desvignes T, Batzel P, Berezikov E, Eilbeck K, Eppig JT, McAndrews MS, Singer A, Postlethwait JH. miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants. Trends Genet. 2015 Nov;31(11):613-626. doi: 10.1016/j.tig.2015.09.002. Epub 2015 Oct 8. PMID: 26453491; PMCID: PMC4639415.
Kumarswamy R, Volkmann I, Thum T. Regulation and function of miRNA-21 in health and disease. RNA Biol. 2011 Sep-Oct;8(5):706-13. doi: 10.4161/rna.8.5.16154. Epub 2011 Jul 7. PMID: 21712654; PMCID: PMC3256347.
Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science. 2001 Oct 26;294(5543):853-8. doi: 10.1126/science.1064921. PMID: 11679670.
Huang Z, Shi J, Gao Y, Cui C, Zhang S, Li J, Zhou Y, Cui Q. HMDD v3.0: a database for experimentally supported human microRNA-disease associations. Nucleic Acids Res. 2019 Jan 8;47(D1):D1013-D1017. doi: 10.1093/nar/gky1010. PMID: 30364956; PMCID: PMC6323994.
Chen Y, Wang X. miRDB: an online database for prediction of functional microRNA targets. Nucleic Acids Res. 2020 Jan 8;48(D1):D127-D131. doi: 10.1093/nar/gkz757. PMID: 31504780; PMCID: PMC6943051.
Bartman CM, Oyama Y, Brodsky K, Khailova L, Walker L, Koeppen M et al. Intense light-elicited upregulation of miR-21 facilitates glycolysis and cardioprotection through Per2-dependent mechanisms. PLoS One. 2017 Apr 27;12(4):e0176243. doi: 10.1371/journal.pone.0176243. PMID: 28448534; PMCID: PMC5407766.
Jazbutyte V, Thum T. MicroRNA-21: from cancer to cardiovascular disease. Curr Drug Targets. 2010 Aug;11(8):926-35. doi: 10.2174/138945010791591403. PMID: 20415649.
Fitzgerald JB, George J, Christenson LK. Non-coding RNA in Ovarian Development and Disease. Adv Exp Med Biol. 2016;886:79-93. doi: 10.1007/978-94-017-7417-8_5. PMID: 26659488; PMCID: PMC5535786.
Wang W, Li X, Liu C, Zhang X, Wu Y, Diao M, Tan S, Huang S, Cheng Y, You T. MicroRNA-21 as a diagnostic and prognostic biomarker of lung cancer: a systematic review and meta-analysis. Biosci Rep. 2022 May 27;42(5):BSR20211653. doi: 10.1042/BSR20211653. PMID: 35441676; PMCID: PMC9093699.
Qiu L, Weng G. The diagnostic value of serum miR-21 in patients with ovarian cancer: a systematic review and meta-analysis. J Ovarian Res. 2022 May 2;15(1):51. doi: 10.1186/s13048-022-00985-3. PMID: 35501921; PMCID: PMC9059364.
Dioguardi M, Spirito F, Sovereto D, Alovisi M, Troiano G, Aiuto R, Garcovich D, Crincoli V, Laino L, Cazzolla AP, Caloro GA, Di Cosola M, Lo Muzio L. MicroRNA 21 Expression as a Prognostic Biomarker in Oral Cancer: Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2022 Mar 14;19(6):3396. doi: 10.3390/ijerph19063396. PMID: 35329083; PMCID: PMC8948874.
Alexandre D, Teixeira B, Rico A, Valente S, Craveiro A, Baptista PV et al. Int J Mol Sci. 2022 Mar 19;23(6):3330. doi: 10.3390/ijms23063330. PMID: 35328750; PMCID: PMC8955680.
Sheng S, Su W, Mao D, Li C, Hu X, Deng W, Yao Y, Ji Y. MicroRNA-21 induces cisplatin resistance in head and neck squamous cell carcinoma. PLoS One. 2022. Apr 14;17(4):e0267017. doi: 10.1371/journal.pone.0267017. PMID: 35421166; PMCID: PMC9009694.
He G, Ding J, Zhang Y, Cai M, Yang J, Cho WC et al. microRNA-21: a key modulator in oncogenic viral infections. RNA Biol. 2021 May;18(5):809-817. doi: 10.1080/15476286.2021.1880756. Epub 2021 Mar 22. PMID: 33499700; PMCID:PMC8078529.
Pandey N, Rastogi M, Singh SK. Chandipura virus dysregulates the expression of hsa-miR-21-5p to activate NF-κB in human microglial cells. J Biomed Sci. 2021 Jul 7;28(1):52. doi: 10.1186/s12929-021-00748-0. PMID: 34233673; PMCID: PMC8265105.
Shi J, Feng P, Gu T. MicroRNA-21-3p modulates FGF2 to facilitate influenza A virus H5N1 replication by refraining type I interferon response. Biosci Rep. 2020 May 29;40(5):BSR20200158. doi: 10.1042/BSR20200158. PMID: 32432671; PMCID: PMC7256676.
Castro-Leyva V, Arenas-Huertero F, Espejel-Núñez A, Giono Cerezo S, Flores-Pliego A, Espino Y Sosa S et al. miR-21 differentially regulates IL-1β and IL-10 expression in human decidual cells infected with streptococcus B. Reprod Biol. 2022 Mar;22(1):100604. doi: 10.1016/j.repbio.2022.100604. Epub 2022 Jan 13. PMID: 35033900.
Na L, Ding H, Xing E, Zhang Y, Gao J, Liu B et al. The predictive value of microRNA-21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28-day mortality in sepsis patients. J Clin Lab Anal. 2020 Mar;34(3):e23103. doi: 10.1002/jcla.23103. Epub 2019 Nov 28. PMID: 31778243; PMCID: PMC7083453.
Yang P, Dong X, Zhang Y. MicroRNA profiles in plasma samples from young metabolically healthy obese patients and miRNA-21 are associated with diastolic dysfunction via TGF-β1/Smad pathway. J Clin Lab Anal. 2020 Jun;34(6):e23246. doi: 10.1002/jcla.23246. Epub 2020 Feb 28. PMID: 32108968; PMCID: PMC7307369.
Liu W, Li Y, Zhao D. Modulation of Vascular Smooth Muscle Cell Multiplication, Apoptosis, and Inflammatory Damage by miR-21 in Coronary Heart Disease. Comput Math Methods Med. 2021 Nov 27;2021:6942699. doi: 10.1155/2021/6942699. PMID: 34873417; PMCID: PMC8643245.
Chen H, Zhang F, Zhang YL, Yang XC. Relationship between circulating miRNA-21, atrial fibrosis, and atrial fibrillation in patients with atrial enlargement. Ann Palliat Med. 2021 Dec;10(12):12742-12749. doi: 10.21037/apm-21-3518. PMID: 35016439.
Tao L, Huang X, Xu M, Qin Z, Zhang F, Hua F et al. Value of circulating miRNA-21 in the diagnosis of subclinical diabetic cardiomyopathy. Mol Cell Endocrinol. 2020 Dec 1;518:110944. doi: 10.1016/j.mce.2020.110944. Epub 2020 Jul 24. PMID: 32717421.
He W, Zhu L, Huang Y, Zhang Y, Shen W, Fang L et al. The relationship of MicroRNA-21 and plaque stability in acute coronary syndrome. Medicine (Baltimore). 2019 Nov;98(47):e18049. doi: 10.1097/MD.0000000000018049. PMID: 31764830; PMCID: PMC6882643.
Schober A, Blay RM, Saboor Maleki S, Zahedi F, Winklmaier AE, Kakar MY et al. MicroRNA-21 Controls Circadian Regulation of Apoptosis in Atherosclerotic Lesions. Circulation. 2021 Sep 28;144(13):1059-1073. doi: 10.1161/CIRCULATIONAHA.120.051614. Epub 2021 Jul 8. PMID: 34233454.
Kilari S, Cai C, Zhao C, Sharma A, Chernogubova E, Simeon M et al. The Role of MicroRNA-21 in Venous Neointimal Hyperplasia: Implications for Targeting miR-21 for VNH Treatment. Mol Ther. 2019 Sep 4;27(9):1681-1693. doi: 10.1016/j.ymthe.2019.06.011. Epub 2019 Jul 3. PMID: 31326400; PMCID: PMC6731518.
Wang J, Wu M. The up-regulation of miR-21 by gastrodin to promote the angiogenesis ability of human umbilical vein endothelial cells by activating the signaling pathway of PI3K/Akt. Bioengineered. 2021 Dec;12(1):5402-5410. doi: 10.1080/21655979.2021.1964895. PMID: 34424813; PMCID: PMC8806924.
Lyall GK, Davies MJ, Ferguson C, Porter KE, Birch KM. In-exercise vascular shear rate during acute continuous and interval exercise: impact on endothelial function and miR-21. J Appl Physiol (1985). 2019 Dec 1;127(6):1754-1762. doi: 10.1152/japplphysiol.00156.2019. Epub 2019 Oct 10. PMID: 31600098.
Go H, Maeda H, Miyazaki K, Maeda R, Kume Y, Namba F et al. Extracellular vesicle miRNA-21 is a potential biomarker for predicting chronic lung disease in premature infants. Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L845-L851. doi: 10.1152/ajplung.00166.2019. Epub 2020 Mar 19. PMID: 32191117.
Liu R, Zhao G, Wang Q, Gong F. Prognostic value of pulmonary ultrasound score combined with plasma miR-21-3p expression in patients with acute lung injury. J Clin Lab Anal. 2022 Mar;36(3):e24275. doi: 10.1002/jcla.24275. Epub 2022 Feb 10. PMID: 35141939; PMCID: PMC8906047.
Ge J, Yao Y, Jia H, Li P, Sun W. Inhibition of miR-21 ameliorates LPS-induced acute lung injury through increasing B cell lymphoma-2 expression. Innate Immun. 2020 Nov;26(8):693-702. doi: 10.1177/1753425920942574. Epub 2020 Jul 29. PMID: 32727244; PMCID: PMC7787552.
Bozzini S, Pandolfi L, Rossi E, Inghilleri S, Zorzetto M, Ferrario G et al. miRNAs Potentially Involved in Post Lung Transplant-Obliterative Bronchiolitis: The Role of miR-21-5p. Cells. 2021 Mar 20;10(3):688. doi: 10.3390/cells10030688. PMID: 33804639; PMCID: PMC8003603.
Lange T, Artelt N, Kindt F, Stracke S, Rettig R, Lendeckel U, Chadjichristos CE, Kavvadas P, Chatziantoniou C, Endlich K, Endlich N. MiR-21 is up-regulated in urinary exosomes of chronic kidney disease patients and after glomerular injury. J Cell Mol Med. 2019 Jul;23(7):4839-4843. doi: 10.1111/jcmm.14317. Epub 2019 May 7. PMID: 31066165; PMCID: PMC6584549.
Wu R, Zhou S, Liu M, An H, Wang Z, Liu T. Clinical Significance of miR-21-5p in Predicting Occurrence and Progression of Uremic Vascular Calcification in Patients with End-Stage Renal Disease. Yonsei Med J. 2022 Mar;63(3):252-258. doi: 10.3349/ymj.2022.63.3.252. PMID: 35184427; PMCID: PMC8860934.
Parrish A, Srivastava A, Juskeviciute E, Hoek JB, Vadigepalli R. Dysregulation of miR-21-associated miRNA regulatory networks by chronic ethanol consumption impairs liver regeneration. Physiol Genomics. 2021 Dec 1;53(12):546-555. doi: 10.1152/physiolgenomics.00113.2021. Epub 2021 Nov 19. PMID: 34796728; PMCID: PMC8820682.
Makhmudi A, Kalim AS, Gunadi. microRNA-21 expressions impact on liver fibrosis in biliary atresia patients. BMC Res Notes. 2019 Mar 29;12(1):189. doi: 10.1186/s13104-019-4227-y. PMID: 30925941; PMCID: PMC6441216.
Xiong Y, Tang Y, Fan F, Zeng Y, Li C, Zhou G et al. Exosomal hsa-miR-21-5p derived from growth hormone-secreting pituitary adenoma promotes abnormal bone formation in acromegaly. Transl Res. 2020 Jan;215:1-16. doi: 10.1016/j.trsl.2019.07.013. Epub 2019 Aug 10. PMID: 31469974.
Zou YC, Gao YP, Yin HD, Liu G. Serum miR-21 expression correlates with radiographic progression but also low bone mineral density in patients with ankylosing spondylitis: a cross-sectional study. Innate Immun. 2019 Jul;25(5):314-321. doi: 10.1177/1753425919842932. Epub 2019 Apr 18. PMID: 30997863; PMCID: PMC6830902.
Suarjana IN, Isbagio H, Soewondo P, Rachman IA, Sadikin M, Prihartono J et al. The Role of Serum Expression Levels of Microrna-21 on Bone Mineral Density in Hypostrogenic Postmenopausal Women with Osteoporosis: Study on Level of RANKL, OPG, TGFβ-1, Sclerostin, RANKL/OPG Ratio, and Physical Activity. Acta Med Indones. 2019 Jul;51(3):245-252. PMID: 31699948.
Weng PW, Yadav VK, Pikatan NW, Fong IH, Lin IH, Yeh CT et al. Novel NFκB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling. Int J Mol Sci. 2021 Oct 14;22(20):11082. doi: 10.3390/ijms222011082. PMID: 34681754; PMCID: PMC8538686.
La Sala L, Mrakic-Sposta S, Tagliabue E, Prattichizzo F, Micheloni S, Sangalli E et al. Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D. Cardiovasc Diabetol. 2019 Feb 25;18(1):18. doi: 10.1186/s12933-019-0824-2. PMID: 30803440; PMCID: PMC6388471.
Huang C, Luo W, Wang Q, Ye Y, Fan J, Lin L et al. Human mesenchymal stem cells promote ischemic repairment and angiogenesis of diabetic foot through exosome miRNA-21-5p. Stem Cell Res. 2021 Apr;52:102235. doi: 10.1016/j.scr.2021.102235. Epub 2021 Feb 11. PMID: 33601096.
Chang WT, Huang TL, Chen ZC, Feng YH. The Expression of MicroRNA-21 in Bone Marrow Fluid is an Indicator of Hematological Disorders and Mortality. Asian Pac J Cancer Prev. 2020 Oct 1;21(10):2817-2821. doi: 10.31557/APJCP.2020.21.10.2817. PMID: 33112535; PMCID: PMC7798149.
Mirza MAB, Guru SA, Abdullah SM, Rizvi A, Saxena A. microRNA-21 Expression as Prognostic and Therapeutic Response Marker in Chronic Myeloid Leukaemia Patients. Asian Pac J Cancer Prev. 2019 Aug 1;20(8):2379-2383. doi: 10.31557/APJCP.2019.20.8.2379. PMID: 31450909; PMCID: PMC6852824.
Moussa Agha D, Rouas R, Najar M, Bouhtit F, Fayyad-Kazan H, Lagneaux L et al. Impact of Bone Marrow miR-21 Expression on Acute Myeloid Leukemia T Lymphocyte Fragility and Dysfunction. Cells. 2020 Sep 8;9(9):2053. doi: 10.3390/cells9092053. PMID: 32911844; PMCID: PMC7563595.
Zhan L, Pang Y, Jiang H, Zhang S, Jin H, Chen J et al Butylphthalide Inhibits TLR4/NF-κB Pathway by Upregulation of miR-21 to Have the Neuroprotective Effect. J Healthc Eng. 2022 Jan 7;2022:4687349. doi: 10.1155/2022/4687349. PMID: 35035839; PMCID: PMC8759846.
Xiao G, Huang B, Guo M, Long C, Li P, Zhong B et al. Long non-coding RNA BRCAT54 sponges microRNA-21 in vestibular schwannoma to suppress cell proliferation. Bioengineered. 2022 Feb;13(2):4301-4308. doi: 10.1080/21655979.2022.2031410. PMID: 35137654; PMCID: PMC8973964.
Xiong Y, Xiong Y, Zhang H, Zhao Y, Han K, Zhang J et al. hPMSCs-Derived Exosomal miRNA-21 Protects Against Aging-Related Oxidative Damage of CD4+ T Cells by Targeting the PTEN/PI3K-Nrf2 Axis. Front Immunol. 2021 Nov 23;12:780897. doi: 10.3389/fimmu.2021.780897. PMID: 34887868; PMCID: PMC8649962.
Tangtanatakul P, Klinchanhom S, Sodsai P, Sutichet T, Promjeen C, Avihingsanon Y et al. Down-regulation of let-7a and miR-21 in urine exosomes from lupus nephritis patients during disease flare. Asian Pac J Allergy Immunol. 2019 Dec;37(4):189-197. doi: 10.12932/AP-130318-0280. PMID: 30118248.
Zhang R, Wu L, Zhang HJ, Gao XJ, Pan XT, Wang XR et al. Expression levels of plasma miRNA-21 and NT-proBNP in children with Kawasaki disease and their clinical significance. Eur Rev Med Pharmacol Sci. 2020 Dec;24(24):12757-12762. doi: 10.26355/eurrev_202012_24175. PMID: 33378024.
Nuñez-Borque E, Fernandez-Bravo S, Rodriguez Del Rio P, Alwashali EM, Lopez-Dominguez D, Gutierrez-Blazquez MD et al. Increased miR-21-3p and miR-487b-3p serum levels during anaphylactic reaction in food allergic children. Pediatr Allergy Immunol. 2021 Aug;32(6):1296-1306. doi: 10.1111/pai.13518. Epub 2021 May 7. PMID: 33876465; PMCID: PMC8453890.
Lu J, Liu D, Tan Y, Deng F, Li R. M1 Macrophage exosomes MiR-21a-5p aggravates inflammatory bowel disease through decreasing E-cadherin and subsequent ILC2 activation. J Cell Mol Med. 2021 Mar;25(6):3041-3050. doi: 10.1111/jcmm.16348. Epub 2021 Feb 10. PMID: 33569850; PMCID: PMC7957199.
Yildirim E, Ermis E, Allahverdiyev S, Ucar H, Yavuzer S, Cengiz M. Circulating miR-21 levels in hypertensive patients with asymptomatic organ damage. Medicine (Baltimore). 2019 Sep;98(39):e17297. doi: 10.1097/MD.0000000000017297. PMID: 31574853; PMCID: PMC6775376.
Kara SP, Ozkan G, Yılmaz A, Bayrakçı N, Güzel S, Geyik E. MicroRNA 21 and microRNA 155 levels in resistant hypertension, and their relationships with aldosterone. Ren Fail. 2021 Dec;43(1):676-683. doi: 10.1080/0886022X.2021.1915800. PMID: 33888045; PMCID: PMC8078961.
Ma R, Li X, Tewari N, Liu Y, Bhawal UK, Zeng X. microRNA-21 ameliorates the impairment of autophagy in palatal wound healing. J Physiol Pharmacol. 2020 Dec;71(6). doi: 10.26402/jpp.2020.6.14. Epub 2021 Apr 22. PMID: 33902001.
Liu R, Du J, Zhou J, Zhong B, Ba L, Zhang J et al. Elevated microRNA-21 Is a Brake of Inflammation Involved in the Development of Nasal Polyps. Front Immunol. 2021 Apr 15;12:530488. doi: 10.3389/fimmu.2021.530488. PMID: 33936025; PMCID: PMC8082185.
Shchurevska OD, Zhuk SI. ASSESSMENT OF CORRELATION BETWEEN MIRNAS-21-3P AND -210-3P EXPRESSION IN MATERNAL AND UMBILICAL CORD PLASMA AND FETAL WEIGHT AT BIRTH. Wiad Lek. 2021;74(2):236-240. PMID: 33813478.
Hu L, Han D, Yu D, Ao D, Yang Z. Circulating Blood miR-155 and miR-21 Promote the Development of Acute Pancreatitis and Can Be Used to Assess the Risk Stratification of Pancreatitis. J Healthc Eng. 2021 Dec 14;2021:2064162. doi: 10.1155/2021/2064162. PMID: 34950438; PMCID: PMC8692001.
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